U.S. President Joe Biden told Israel's Prime Minister Benjamin Netanyahu that he expects "significant de-escalation" on Wednesday in the military confrontation with the Palestinians, amid intense efforts to reach a ceasefire.

Deafening air strikes and rocket fire once more shook Gaza in the conflict that has, since May 10, claimed 219 Palestinian lives according to the Gaza health ministry and killed 12 people in Israel according to Israeli police.

Israeli airstrikes killed at least six people across the Gaza Strip and destroyed the home of a large extended family early on Wednesday. The military said it widened its strikes on militant targets to the south amid continuing rocket fire from the Hamas-ruled territory.

Residents surveyed the piles of bricks, concrete and other debris that had once been the home of 40 members of al-Astal family. They said a warning missile struck the building in the southern town of Khan Younis five minutes before the airstrike, allowing everyone to escape.

Saudi Arabia is "hopeful" after exploratory talks with its nemesis Iran, its foreign minister told AFP, in a rare comment on delicate discussions whose details have been closely guarded.

Chile's Palestinian community -- the largest outside the Middle East with more than 300,000 people -- protested Tuesday in Santiago against the bloodshed caused by Israeli airstrikes. 

German Chancellor Angela Merkel and Jordan's King Abdullah II urged a "swift" ceasefire in the conflict between Israel and Palestinian militant group Hamas in a video call Tuesday, her spokesman said.

Israeli troops were targeted by gunfire in the occupied West Bank on Tuesday, the army said, as the Palestinian health ministry said a man was killed in a separate shooting.

EU foreign policy chief Josep Borrell on Tuesday called for the implementation of a ceasefire to stop fighting between Israel and the Palestinians.

Heavy air strikes and rocket fire in the Israel-Gaza conflict claimed more lives on both sides Tuesday as tensions flared in Palestinian "day of anger" protests in Jerusalem and the occupied West Bank.

Egypt has sent 65 tonnes of medical aid to neighbouring Gaza after a week of Israeli strikes left more than 200 Palestinians dead and hundreds more wounded, health officials said.

France's President Emmanuel Macron, his Egyptian counterpart Abdel Fattah al-Sisi and Jordan's King Abdullah II held talks Tuesday aimed at seeking a ceasefire in the conflict between Israel and Palestinian militant group Hamas.