An Israeli airstrike on a home killed 16 people, half of them children, in the southern Gaza town of Rafah, medics said early Thursday. The military continued to strike targets in areas of the besieged territory where it has told civilians to seek refuge.

There was meanwhile no word on whether medicines that entered the territory Wednesday as part of a deal brokered by France and Qatar had been distributed to dozens hostages with chronic illnesses who are being held by Hamas.

At least nine civilians, including two children, were killed Thursday in air strikes on Syria likely to have been carried out by Jordan against drug-traffickers, a monitor and media outlet reported.

The kingdom has tightened controls along its frontier with Syria in recent years and its armed forces occasionally announce operations to foil drug and weapon smuggling attempts from its war-torn neighbour.

Fighting "human animals." Making Gaza a "slaughterhouse." "Erasing the Gaza Strip from the face of the earth."

Such inflammatory rhetoric is a key component of South Africa's case accusing Israel of genocide at the U.N. world court, a charge Israel denies. South Africa says the language — in comments by Israeli leaders, soldiers and entertainers about Palestinians in Gaza since Hamas' Oct. 7 attack sparked war — is proof of Israel's intent to commit genocide.

American forces targeted 14 missiles that were ready to launch in Yemen, the U.S. military said Wednesday, after Washington re-designated the Iran-backed Houthi rebels as a "terrorist" entity for their attacks on merchant vessels.

The Houthis -- who have already faced multiple rounds of air strikes in response to their targeting of international shipping -- struck a U.S.-owned bulk cargo carrier in the wake of the designation announcement, and vowed to continue attacks they say are in support of Palestinians in Gaza.

U.S. Secretary of State Antony Blinken reiterated the need for a "pathway to a Palestinian state" Wednesday at the World Economic Forum's annual meeting in the Swiss resort of Davos, saying that Israel would not "get genuine security absent that."

If Israel can be brought into the fold of the Middle East, Blinken said, the region would be coming together to isolate Iran, which he called "the biggest concern in terms of security," as well as its proxies, which include Yemen's Houthi rebels who have been attacking commercial ships in the Red Sea.

The Biden administration is expected to soon announce plans to redesignate Iranian-backed Houthi rebels in Yemen as specially designated global terrorists, according to two people familiar with the White House decision and a U.S. official.

The move comes as the Houthis have launched dozens of attacks on commercial vessels in the Red Sea. The group says it has attacked the ships in response to Israel's military operations in Gaza in the aftermath of Hamas' Oct. 7 attack on Israel.

Over the past three months, on banners and T-shirts and balloons and social media posts, one piece of imagery has emerged around the world in protests against the Israel-Hamas war: the watermelon.

The colors of sliced watermelon — with red pulp, green-white rind and black seeds — are the same as those on the Palestinian flag. From New York and Tel Aviv to Dubai and Belgrade, the fruit has become a symbol of solidarity, drawing together activists who don't speak the same language or belong to the same culture but share a common cause.

A barrage of U.S., coalition and militant attacks in the Middle East over the last five days are compounding U.S. fears that Israel's war on Hamas in Gaza could expand, as massive military strikes failed to stall the assault on Red Sea shipping by Yemen-based Houthis.

Even as the U.S. and allies pummeled more than two dozen Iran-backed Houthi locations on Friday in retaliation for attacks on ships, the Houthis have continued their maritime assaults. And Tehran struck sites in Iraq and Syria, claiming to target an Israeli "spy headquarters," then followed that Tuesday with reported missile and drone attacks in Pakistan.

Ahmed Abdullah Abu Shalal, who the Israeli military said was responsible for infrastructure and had planned multiple attacks against Israelis in Jerusalem, was killed along with four others early Wednesday in the built-up Balata refugee camp in the city of Nablus.

The Palestinian Red Crescent said Israeli forces prevented medics from reaching the site of the strike, saying in a social media post that “gunfire was directed at our teams.”

A shipment of medicine for dozens of hostages held by Hamas was en route to Gaza on Wednesday after France and Qatar mediated the first agreement between Israel and the militant group since a weeklong cease-fire broke down in November.

The medicines will be shipped through Egypt and delivered to the International Committee of the Red Cross, which will then hand them over to Hamas. Qatar said the deal also includes the delivery of additional medicine and humanitarian aid to Palestinians in the besieged coastal enclave.