Yemen's Houthi rebels fired an anti-ship cruise missile toward an American destroyer in the Red Sea on Sunday, but a U.S. fighter jet shot it down in the latest attack roiling global shipping amid Israel's war with Hamas in the Gaza Strip, officials said.

The attack marks the first U.S.-acknowledged fire by the Houthis since America and allied nations began strikes Friday on the rebels following weeks of assaults on shipping in the Red Sea.

Now 100 days old, the latest Israel-Hamas war is by far the longest, bloodiest, and most destructive conflict between the bitter enemies.

The fighting erupted on Oct. 7 when Hamas carried out a deadly attack in southern Israel. Since then, Israel has relentlessly pounded the Gaza Strip with airstrikes and a ground offensive that have wrought unprecedented destruction, flattening entire neighborhoods. The offensive has displaced the vast majority of Palestinians in Gaza, shuttered operations in more than half of Gaza's hospitals and caused widespread hunger, U.N. monitors say.

Officials in Hamas-run Gaza said on Monday dozens were killed overnight in "intense" Israeli bombardment, as the war which has sent shockwaves across the region passed the grim 100-day milestone.

Deadly violence in the Israeli-occupied West Bank and along Israel's border with Lebanon as well as fighting between U.S. forces and Iran-backed Yemeni rebels in the Red Sea have raised fears of an escalation beyond the Gaza Strip.

Israeli soldiers detained two sisters of Saleh al-Arouri, a top leader of Hamas who was killed in Lebanon this month, Palestinian sources and the Israeli army said on Sunday.

The killing of Arouri, the deputy chief of Hamas, in a southern suburb of Beirut on January 2 was widely attributed to an Israeli drone strike, fuelling fears that Israel's war in Gaza could widen into a regional conflict.

South Africa says more than 50 countries have expressed support for its case at the United Nations' top court accusing Israel of genocide against Palestinians in the war in Gaza.

Others, including the United States, have strongly rejected South Africa's allegation that Israel is violating the U.N. Convention on the Prevention and Punishment of the Crime of Genocide. Many more have remained silent.

Thousands of demonstrators converged opposite the White House to call for an end to Israeli military action in Gaza, while children joined a pro-Palestinian march through central London as part of a global day of action against the longest and deadliest war between Israel and Palestinians in 75 years.

People in the U.S. capital held aloft signs questioning President Joe Biden's viability as a presidential candidate because of his staunch support for Israel in the nearly 100-day war against Hamas. Some of the signs read: "No votes for Genocide Joe," "Biden has blood on his hands" and "Let Gaza live."

Israel will pursue its war against Hamas until victory and will not be stopped by anyone, including the world court, Prime Minister Benjamin Netanyahu said in a defiant speech, as the fighting in Gaza approached the 100-day mark.

Netanyahu spoke after the International Court of Justice at The Hague held two days of hearings on South Africa's allegations that Israel is committing genocide against Palestinians, a charge Israel has rejected as libelous and hypocritical. South Africa asked the court to order Israel to halt its blistering air and ground offensive in an interim step.

More than 30 Palestinians, including young children, were killed in two Israeli airstrikes overnight into Saturday in the Gaza Strip, officials said, as concerns continued to grow over a lack of fuel and supplies for overburdened hospitals.

Video provided by Gaza's Civil Defense department showed rescue workers searching through the twisted rubble of a home in Gaza City by flashlight early Saturday morning after it was hit by an Israeli attack.

The U.S. military early Saturday struck another Houthi-controlled site in Yemen that it had determined was putting commercial vessels in the Red Sea at risk, a day after the U.S. and Britain launched multiple airstrikes targeting Houthi rebels.

Associated Press journalists in Sanaa, Yemen's capital, heard one loud explosion.

The head of the World Health Organization said Friday that Gaza’s main hospital has begun partially functioning once again, after an Israeli operation in early November forced it to shut down.

Director Tedros Gebreysus wrote on X, formerly called Twitter, that the organization has delivered 9,300 liters (2,460 gallons) of fuel to Shifa Hospital in Gaza City, allowing a 60-person medical team to begin treating over 1,000 patients. He said Shifa now has a working emergency room and a surgical ward with 40 beds.