Egyptian police and protesters clashed in the center of the capital and in the port city of Suez on Wednesday, the second day of anti-government rallies that had been threatened with a massive security crackdown.
With the interior ministry having banned all protests, police fired tear gas at hundreds of people gathered near the journalists' syndicate in Cairo demanding the ouster of President Hosni Mubarak, an Agence France Presse reporter said.
Protesters chanted "The people want the ouster of the regime," and threw rocks at police in response to the tear gas.
In Suez, where three demonstrators died on Tuesday, witnesses told AFP police used batons to try disperse at least 2,000 protesters gathered outside a morgue and chanting "Down with Mubarak."
Riot police trucks lined the streets of downtown Cairo where thousands had gathered the day before to demand that Mubarak step down.
Officials said four people -- three protesters and a policeman -- had died in Tuesday's protest in a "day of anger" inspired by the uprising in Tunisia.
The United States, a key Egyptian ally, said Cairo should be "responsive" to its people's aspirations, while both France and Germany urged restraint on all sides.
An Egyptian security official told AFP around 200 people had been detained by Wednesday in the largest protests in Egypt since bread riots in 1977.
Security forces had surrounded the journalists' syndicate on Wednesday, briefly detaining one of its board members.
The pro-democracy youth group April 6 Movement, the driving force behind Tuesday's protests, had urged people to head back to Cairo's main square on Wednesday.
This despite the fact that in the early hours of Wednesday, police had ended the Cairo protests by firing tear gas and rounding up protesters, with reports of dozens arrested or missing.
"Everyone needs to head down to Tahrir Square to take over the square once again," the group said on its Facebook page which, along with Twitter, had helped to organize Tuesday's protests.
In a separate statement, it urged Egyptians to carry on protesting.
"To continue what we started on January 25, we will take to the streets to demand the right to life, liberty, dignity and we call on everyone to take to the streets ... and to keep going until the demands of the Egyptian people have been met," the group said.
The interior ministry said further demonstrations were banned and anyone taking part would be prosecuted.
"No provocative moves, or protest gatherings, or marches or demonstrations will be allowed," the ministry said.
"Legal measures will be taken against anyone (in contravention), and they will be transferred to the prosecution," a statement continued.
April 6 Movement members said they would take to the streets regardless.
"We've started and we won't stop," one told AFP on Wednesday.
On Tuesday, a police deployment of some 20,000 to 30,000 personnel had allowed demonstrators to march to Tahrir Square, where they chanted in unison: "The people want the ouster of the regime."
Demonstrators also tore down posters of Mubarak and chanted, "Mubarak get lost," "Bread, liberty, dignity," and "We will follow Tunisia."
Among demands are the departure of the interior minister, whose security forces have been accused of heavy-handedness; an end to a decades-old state of emergency; and a rise in minimum wages.
Late Tuesday, the interior ministry said security forces had decided to allow demonstrators "to voice their demands and exercise their freedom of expression," with a commitment to "securing and not confronting these gathering".
But it accused the Muslim Brotherhood of rioting and causing public disorder, which the group denied.
Egypt's stock market saw a sharp decline and the Egyptian pound hit a six-year low to reach 5.83 to the dollar a day after the mass protests.
The White House said on Tuesday that Egypt's government should be "responsive" to its people's aspirations.
"The Egyptian government has an important opportunity to be responsive to the aspirations of the Egyptian people, and pursue political, economic and social reforms that can improve their lives and help Egypt prosper," a statement said.
French Foreign Minister Michele Alliot-Marie said in Paris on Wednesday that France regrets the loss of life in the anti-government protests and supports calls for more democracy "in all countries."
"I can only deplore that there were deaths ... One must be able to demonstrate without there being violence, let alone deaths," she told France's RTL radio.
German Foreign Minister Guido Westerwelle said Berlin was "very worried" by unrest in Egypt and called on all sides to refrain from violence.
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